These criteria are divided into six clinical domains—macrovascular venous thromboembolism, macrovascular arterial thrombosis, microvascular thrombosis, obstetrics, heart valve involvement, and hematology—and two laboratory domains: lupus anticoagulant functional coagulation assay and solid-phase ELISA tests for detecting IgG/IgM anti-cardiolipin and/or IgG/IgM anti-beta-2 glycoprotein I antibodies. Here, CD40LG is linked to venous thromboembolism.