Similar to patients with severe aortic stenosis, our cohort with an AVWS-like phenotype exhibited a significantly reduced VWF-LMI (75.5 ± 7.3 vs 108.1 ± 14.7; P < .001), falling <0.8 threshold established by Tamura et al. [18]. The gene discussed is VWF; the disease is aortic stenosis.