The Ki-67 index revealed that all of the anticancer agents significantly suppressed tumor growth in vivo compared with no treatment control (CDDP: p = 7.35E-04; Cmab: 1.02E-04; and DKK3-CP: 8.220E-06), while there were no significant differences in Ki-67 indices between the groups (Figure 4B). This evidence concerns the gene DKK3 and neoplasm.