Hereditary angioedema (HAE) is a rare, genetic disorder, attributed in most cases to the SERPING 1 gene mutations, resulting in functional (HAE-C1INH type1) or quantitative (HAE-C1INH type2) deficiency of the C1 esterase inhibitor (C1INH) protein (1, 2). Here, SERPING1 is linked to hereditary disease.