According to the data, the most frequently mutated genes in myogenic CIPO were ACTG2 (72.41%, 21/29) and FLNA (13.79%, 4/29), while in neurogenic CIPO, the prevalent mutations were RET (20%, 5/25) and 9p21.3 duplication (24%, 6/25). The gene discussed is ACTG2; the disease is chronic intestinal pseudoobstruction.