At the molecular mechanism level, the core mediators of heart-liver interaction include: (1) Inflammatory signal cascade (Correale et al., 2018):Myocardial infarction induces inflammatory responses in the liver and leads to liver injury, while exercise-induced myogenic factor Irisin inhibits liver inflammatory responses and improves liver injury caused by myocardial infarction (Wang et al., 2023a). This evidence concerns the gene FNDC5 and myocardial infarction.