Romana-Souza et al. [50] studied the restorative effect of caffeic acid phenethyl ester (CAPE) on pressure ulcers through in vivo experiments, and the results showed that NF-κB was involved in the inflammatory reaction of pressure ulcers, leading to chronic inflammation and delaying wound closure, and CAPE might reduce the activation of NF-κB P65 and promote wound healing [51,52,53,54,55]. This evidence concerns the gene NFKB1 and decubitus ulcer.