NDUFA13 and colorectal carcinoma: Of note, in CRC, hypoxia may regulate EMT through the gene associated with retinoid-interferon-induced mortality-19 (GRIM-19), which blocks EMT by suppressing hypoxia-dependent-autophagy (Zhang et al., 2019), and consistently, it is downregulated in CRC patients (Hao et al., 2015).