When PFK1 activity is suppressed, glucose-6-phosphate (G-6-P), an upstream metabolite of PFK1, is capable of being transformed into ribose-5-phosphate and NADPH via the pentose phosphate pathway (PPP), which gives tumor cells the raw materials they need for biosynthesis (Campos and Albrecht, 2023). This evidence concerns the gene PFKM and neoplasm.