However, some research has shown that MCT4 expression is higher in thyroid cancer cells, particularly in undifferentiated thyroid cancer; MCT4 can also make the tumor microenvironment more acidic, encourage the buildup of lactate, and suppress immune cell activity (Silva et al., 2023; Khatami et al., 2019). The gene discussed is SLC16A3; the disease is thyroid gland carcinoma.