In colorectal cancer (CRC), Wnt signaling is a key driver of tumor progression, with its dysregulation commonly occurring due to Adenomatous Polyposis Coli (APC) mutations that stabilize β-catenin, leading to the constitutive activation of Wnt target genes (Fu et al., 2018; Liu and Yin, 2017). The gene discussed is APC; the disease is neoplasm.