ATG5 and acute myeloid leukemia: In conclusion, our study uncovers a critical link between autophagy and the PI3K/AKT/mTOR signaling pathway in AML cells, demonstrating that combined treatment with PI3K/AKT/mTOR inhibitors leads to significant upregulation of autophagy-related genes such as Beclin-1, LC3-II, ATG5, and ATG7 (Fig. 6).