For example, BDNF-driven neuroplasticity (cluster 1) underlies manic/depressive cycling in BD (Yang et al. 2020) and cognitive resilience in UD, while SH2B3/NKPD1 in cluster 7 implicates neuroinflammation and synaptic pruning pathways common to MS, BD, UD, and SZ (Wang et al. 2011). The gene discussed is SH2B3; the disease is Behcet disease.