Regardless of its evolutionary origins, a variety of health changes have been associated with the menopause transition, including increased levels of low density lipoprotein (LDL) cholesterol, non-high density lipoprotein (non-HDL) cholesterol, varied levels of triglycerides and apolipoprotein-B (Apo-B), changes in LDL and HDL cholesterol particle size, cognitive declines, and decreasing levels of estradiol [16–21]. The gene discussed is APOB; the disease is Mental deterioration.