TP53 and endometrial clear cell adenocarcinoma: Furthermore, recent molecular evidence indicates that the endometrioid subtype of endometrial adenocarcinoma, known as type 1 tumors, is linked to hyperestrogenism, while serous and clear cell carcinomas of the endometrium, categorized as type 2 tumors, primarily result from mutations in the tumor suppressor gene p53 [17, 18].