Moreover, compared to ccRCC and tRCC, the ribosome biogenesis-related proteins RPF2 and GNL2 demonstrated both significantly elevated median expression levels and higher identification frequencies in CDC, supporting their potential utility as diagnostic biomarkers for CDC (Data S4). The gene discussed is GNL2; the disease is renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.