Gene set enrichment analysis (GSEA) revealed that tumor-enriched proteins were associated with pathways such as ribosome biogenesis, DNA replication, extracellular matrix (ECM) organization, innate immune response, and cell migration (Fig. 4B), whereas NAT-enriched proteins were mainly involved in pathways related to biological metabolism (including the metabolism of fatty acid, amino acid, and glucose) and kidney development (Fig. 4B). The gene discussed is BRD2; the disease is neoplasm.