Notably, FUBP1 was the protein most associated with OS (Fig. 3G) in this cohort, which has been reported as a major regulator of transcription, translation, and RNA splicing, and has also been implicated as an oncoprotein overexpressed in multiple malignancies, including hepatocellular carcinoma (HCC), non-small cell lung cancer, breast cancer, and ccRCC [29]. Here, FUBP1 is linked to hepatocellular carcinoma.