Notably, compared to CDC, the significantly up-regulated glycolysis, angiogenesis, and CA9 expression (Data S4) [59] in ccRCC, as well as significantly enhanced OXPHOS in tRCC, demonstrated the unique molecular profile of different RCC types and the diagnostic reliability of our CDC cohort. Here, CA9 is linked to renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.