In support of the notion that hippocampal CaMKII plays a critical role in ORM destabilization, pre-reactivation intra-dorsal CA1 administration of AIP prevented the amnesia caused by ANI (Figure 3a; F(1,38) = 4.418, p = 0.0422 for Pre-RA Treatment; F(1,38) = 6.451, p = 0.0153 for Post-RA Treatment and F(1,38) = 6.339, p = 0.0161 for Interaction; t(38) = 3.593, p < 0.01 for VEH + VEH vs. VEH + ANI; t(38) = 3.136, p < 0.05 for AIP + VEH vs. VEH + ANI and t(38) = 3.349, p < 0.05 for AIP + ANI vs. VEH + ANI in Bonferroni’s multiple comparisons test after two-way ANOVA). The gene discussed is AIP; the disease is asymptomatic neurocognitive impairment.