Bearing in mind that it has been reported that periodontitis-related epigenetic mechanisms are predicted to enhance viral entry pathways and modulate the host antiviral response related to COVID-19 (3), the most abundant epigenetic-like mechanism, N6-methyladenosine (m6A) RNA methylation, known to regulate gene expression during inflammation (4), becomes particularly relevant; thus, we selected methyl-transferase-like 3 (METTL3), a key m6A “writer,” for investigation, based on prior evidence indicating that its expression is specifically altered in response to SARS-CoV-2 infection. Here, METTL3 is linked to COVID-19.