The implication of the GABAergic system (GABAa) suggests potential disruption in inhibitory control, relevant to anxiety and stress coping (63–65), while the link to the metabotropic glutamate receptor mGluR5 highlights the involvement of excitatory glutamate signaling, a system profoundly sensitive to stress and crucial for synaptic plasticity (66–68). Here, GRM5 is linked to Anxiety.