Hao et al. discovered that MGMT methylation can also serve as a specific biomarker to classify lipid metabolism patterns between methylated and unmethylated GBM[178] and proposed the potential development of atorvastatin in the treatment of GBM with unmethylated MGMT.[179] De Martino et al. found that radiation therapy can promote unsaturated FAs, creating a suitable lipid growth environment for GBM and driving GBM resistance. The gene discussed is MGMT; the disease is glioblastoma.