Recent studies have revealed that regulating lipid metabolism, such as SOAT1,[175] may reduce resistance to radiotherapy/chemotherapy, thereby increasing the survival rate of glioma patients.[176] Ancient ubiquitous protein 1 (AUP1) is believed to regulate LD catabolism and has recently been identified as a poor predictive biomarker associated with tumor proliferation, reflecting neuroinflammatory conditions.[177] The unmethylated promoter region of O6‐methylguanine‐DNA methyltransferase (MGMT) is an important biomarker for identifying chemo‐resistant subtypes of GBM. Here, AUP1 is linked to central nervous system cancer.