An additional intriguing, albeit purely theoretical, hypothesis—and the only potential link to the patient's Kartagener's syndrome that we can currently suggest—is that the very low-frequency presence of the p16-Leiden variant in the buccal swab DNA is due to contamination by mutant cells originating from the esophageal polyp as a result of gastrointestinal reflux secondary to the patient's diaphragmatic hernia. Here, CDKN2A is linked to diaphragmatic hernia.