A total of 23 genes (GAS6, SERPING1, PLSCR1, CYP1B1, CTNNAL1, ATF3, TNFSF10, ADM, S100A8, C1QB, BPGM, GADD45G, FGF13, MYOM2, JAK2, SOCS3, KCNJ2, CLEC2B, C1QA, CHPT1, KREMEN1, C1QC, CMBL) were identified as Shared cross-talk genes between TB and T2DM based on the intersection of WGCNA modules and DEGs (Figure 1F). The gene discussed is S100A8; the disease is type 2 diabetes mellitus.