Stimulated by high glucose levels and ESAT-6, the protein levels of NOD2 and TRAF-6 were markedly reduced, suggesting the crucial function of CYP1B1 in regulating the inflammatory response of the TB-T2DM comorbidity via the modulation of NOD2 and TRAF-6. Here, CYP1B1 is linked to type 2 diabetes mellitus.