Furthermore, expression patterns from external datasets revealed three key cross-talk genes linking TB-T2DM: CYP1B1, SERPING1, and CHPT1. Notably, only CYP1B1 was significantly upregulated in the THP-1 detection test, compared to the unstimulated (control) group (P < 0.05). The gene discussed is CYP1B1; the disease is type 2 diabetes mellitus.