SERPING1 and type 2 diabetes mellitus: The four machine learning methods, expression pattern analysis, and ROC curve evaluation across multiple dimensions identified three key genes from the 23 shared genes: CYP1B1, SERPING1, and CHPT1. Pathway enrichment analysis of the three genes revealed their potential roles in immune responses, inflammation, lipid metabolism, cell growth, and immune evasion in both T2DM and TB.