Additional genetic mutations were identified in 12 of the 39 patients who developed to AML, with mutations in genes such as NPM1, FLT3-ITD, FLT3-D835, TET2, DNMT3A, IDH1, RUNX1, SRSF2, CEBPA, WT1, ATRX, CSMD1, IKZF1, LRP1B, PRPF8, NR2E1, ATM, KRAS, PHF6, MYC, and MLL amplifications. The gene discussed is DNMT3A; the disease is acute myeloid leukemia.