TNFSF11 and Hyperglycemia: Hyperglycemia and oxidative stress in diabetic conditions stimulate RANKL expression while suppressing OPG expression, disrupting the OPG/RANKL balance (90), Qi et al. (71) found that AEBR effectively reduced the overexpression of RANKL in diabetic rats, ultimately restoring the OPG/RANKL ratio and thereby inhibiting excessive osteoclast activity.