TFE3 serves as the master transcriptional regulator of autophagy and lysosomal activity, regulating lysosomal and autophagic pathways.[19, 20] Clinically, high stromal TFE3 expression correlated with poorer outcomes, as TCGA‐PRAD patients with elevated TFE3 exhibited a poorer 5‐year disease‐free survival rate (Figure S2E, Supporting Information). Here, TFE3 is linked to prostate adenocarcinoma.