In contrast, opioids act by binding to mu‐opioid receptors in the central nervous system, effectively blocking pain signals and inducing analgesia but may present various challenges including tolerance, dependence, opioid‐induced hyperalgesia, cognitive impairment, propensity for falls and fractures, and overdose—especially at higher doses when odds of respiratory depression increase [34, 36]. Here, OPRM1 is linked to Respiratory insufficiency due to muscle weakness.