In contrast, opioids act by binding to mu‐opioid receptors in the central nervous system, effectively blocking pain signals and inducing analgesia but may present various challenges including tolerance, dependence, opioid‐induced hyperalgesia, cognitive impairment, propensity for falls and fractures, and overdose—especially at higher doses when odds of respiratory depression increase [34, 36]. This evidence concerns the gene OPRM1 and Cognitive impairment.