As a result of the cancer genomic panel, FLCN H429fs*39 and MLH1 A681T were suspected to be germline pathological variants (PGPV), and germline sequences of FLCN chr17: 17216395 and MLH1 chr3: 37048955 were assessed by NGS (Kazusa DNA Research Institute, Chiba, Japan). This evidence concerns the gene MLH1 and cancer.