In WD + CS hearts, the PC stimulus increased oxidative phosphorylation proteins, dilated cardiomyopathy, neutrophil extracellular trap, RhoGDI, and xenobiotic metabolism AHR signaling proteins, and proteins associated with the TCA cycle, glycolysis, and fatty acid ß‐oxidation; and reduced mitochondrial dysfunction, ILK, actin cytoskeleton, leukocyte extravasation, integrin, VEGF, paxillin, and RhoA/Rho GTPase family/Rho regulation of actin motility, cardiac hypertrophy, and macrophage classical activation signaling proteins (Figure S9). Here, ARHGDIA is linked to cardiac hypertrophy.