ESR1 and Wilson disease: In hearts from WD mice, the PC stimulus: increased oxidative phosphorylation, sirtuin, granzyme A, estrogen receptor, neutrophil extracellular trap, immunogenic cell death, and xenobiotic metabolism AHR and PXR signaling proteins, together with TCA cycle, glycolysis, and gluconeogenesis proteins; and reduced mitochondrial dysfunction, together with leukocyte extravasation signaling and macrophage classical activation signaling proteins (Figure S8).