WB and immunohistochemical staining analysis showed that the levels of the inflammatory factors COX2, CXCL15, TNF-α, NF-κB and p − NF − κB in the model group were significantly higher than those in the control group, indicating that DKD-related renal pathological injury was closely related to inflammation, which was consistent with the results of previous studies. The gene discussed is NFKB1; the disease is diabetic kidney disease.