The RUNX family (RUNXs) of transcription factors, including RUNX1–3, play key regulatory roles in cellular activities such as proliferation, differentiation, and apoptosis.28,29 Emerging evidence suggests that RUNXs function as either tumor suppressors or oncogenes in different types of human cancer.12,30,31 The duality of RUNX family roles suggests that the functions of these regulatory factors are extremely complex. Here, RUNX1 is linked to cancer.