GSDMD and obesity due to melanocortin 4 receptor deficiency: Another study displays that it can inhibit obesity-induced excessive activation of Caspase-1 in stellate sympathetic ganglion,22 whereas activated Caspase-1 can cleave GSDMD into C- and N-terminal, in which GSDMD-NT, as the pyroptotic executioner, induces proinflammatory cell death.16