These data further corroborated the pivotal role of RBMX in transmitting miR-338-3p from BCCs to cardiomyocytes in DOXIC and suggested that blocking miR-338-3p transmitting by interfering its RBMX-mediated packaging mechanism was effective in preventing BCC-induced DOXIC aggravating effects and the detrimental communication between breast cancer cells and cardiomyocytes in DOXIC. Here, RBMX is linked to skin basal cell carcinoma.