Furthermore, compared with sEVs derived from nontreated BCCs (N-BCC-sEVs), sEVs derived from DOX-treated 231 cells (D-BCC-sEVs) markedly worsened DOX-induced cell death, cell viability loss and cTnI leakage in hiCM (Fig. 2F–H-J). This evidence concerns the gene TNNI3 and skin basal cell carcinoma.