GHR and acromegaly: In the cohort of 65 patients diagnosed with acromegaly, patients cured only through surgery were more frequently classified as grade 1 (19: 54.3%) and grade 2 (14: 40%) of the PANOMEN-3 score; patients who needed first line medical therapies (DAs and fg-SRLs) after neurosurgery were more frequently classified as grade 2 of the PANOMEN-3 score (DAs: 51.7%, fg-SRLs: 64.3%); and patients who underwent neurosurgery and needed second line therapies (second generation SRLs or GHR antagonist) were more frequently classified as grade 2 (66.3%) and as grade 3 (33.3%).