For instance, TEAD1 is a component of the Hippo pathway that has been found to exert immunomodulatory effects in murine models of colitis,34 and ARID5A, regulates the expression of genes downstream of the Th17/IL-17 axis,35,36 a pathway known to play a critical role in IBD pathogenesis.37 This evidence concerns the gene IL17A and colitis.