CST3 and diabetes mellitus: There were 8 cohorts with cystatin C available, including 453,628 individuals, and the mean age was 57 years, 53% were female, the mean BMI was 28 kg/m2, 6% had diabetes, the median ACR was 6 mg/g, and mean eGFRcr-cys was 94 mL/min/1.73 m2 (Table 1 and Table S3).