Recent studies further reveal that anesthesia-induced tau hyperphosphorylation enhances excitatory input from the hippocampal CA1 region to anterior cingulate cortex (ACC) pyramidal neurons, while inhibition of tau phosphorylation attenuates ACC hyperactivity and mitigates anesthesia-related cognitive deficits (Chen et al., 2024a). Here, MAPT is linked to Cognitive impairment.