AKT3 and cancer: In addition, miR193b-3p high expression has also been associated with lower cancer cell differentiation, higher TNM stage and lymph node metastases in non-small cell lung cancer, by targeting TP53 pathway, cell-cell adhesion, cytoskeleton remodeling or autophagy (AKT3, IGF-1R), underlining the complex role of such miR [32].