To this end, it has been reported that heparin canhelp treating sepsis, as it inhibits heparinase activity and HMGB1-mediatedLPS cellular uptake. Recently, an octadecasaccharideof heparin turned out to mitigate inflammatory damage in sepsis bytargeting several mediators, including HMGB1. Therefore, it is not surprising that HMGB1, which can be considereda prototypic DAMP, gained interest as a therapeutic target. HMGB1 binds with high affinity to negativelycharged polyanions through its lysine- and arginine-rich A- and B-boxDNA-binding domains. This evidence concerns the gene HMGB1 and Sepsis.