TCF12 is one example of varied levels of dysregulation among the excitatory subtypes associated with distinct cortical layers, with all showing increased skipping in FTD of an alternative exon, but with SEMA3E-marked L4–6 cells demonstrating the strongest ΔΨ, while RORB-marked L3–5 cells and CUX2-marked L2–3 exhibited case-control differences of smaller magnitude (Figure S15F). This evidence concerns the gene CUX2 and frontotemporal dementia.