Our study identified three different and rare recessive alleles likely associated with syndromic forms of albinism and depigmentation in Simmental cattle, affecting TYR, GRID1, and RAD54B. These findings reveal unexpected genetic heterogeneity underlying pigment disorders in livestock and introduce two potential novel candidate genes (GRID1 and RAD54B) with currently unknown roles in melanocyte development and syndromic conditions. The gene discussed is GRID1; the disease is albinism.