Obesity, the main hallmark of the MetS, modifies the phenotype of white adipose tissue, characterized by the presence of dysfunctional and inflamed adipocytes that secrete, both locally and systemically, proinflammatory cytokines such as TNFα, IL‐1β, and IL‐6, which alter the functionality of other target organs [70] including the liver [71]. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.