NOD2 and bacterial infectious disease: NOD2 is an intracellular pattern recognition receptor that detects bacterial components and plays a key role in defending against bacterial infections and maintaining immune homeostasis.[16] Based on the previous results, we hypothesized that S. saprophyticus exacerbates T‐2 toxin‐induced hepatic macrophage homeostasis disruption by being recognized by NOD2 during its translocation from the gut to the liver.