HMOX1 and hematocrit: As a result of itaconate‐driven post‐translational modifications, NRF2 is released and translocated to the nucleus, where it initiates the transcription of antioxidant genes, such as NADPH quinone oxidoreductase 1, glutathione, and HO‐1.[60] Here, we found that 4‐OI attenuates myocardial IR injury after HT.