APOE and neoplasm: Differential gene expression analysis identified 254 genes exhibiting significant alterations (adjusted p < 0.05), with notable upregulation of immunoregulatory genes such as APOE and APOC1, major histocompatibility complex (MHC) class II components including HLA‐DRA, complement system factors (C1QA, C1QB, C1QC), and pro‐inflammatory mediators (IL1B, CCL3) in CD8+ T cells localised to the tumour core (Figure 5A,B).