Of particular note, GBM exhibited significant upregulation of NUCB2, alongside other malignancies such as breast carcinoma (BRCA), oesophageal carcinoma (ESCA), head and neck squamous cell carcinoma (HNSC), kidney chromophobe carcinoma (KICH), liver hepatocellular carcinoma (LIHC), lung adenocarcinoma (LUAD), colorectal adenocarcinoma (READ), skin cutaneous melanoma (SKCM), stomach adenocarcinoma (STAD) and thyroid carcinoma (THCA). The gene discussed is NUCB2; the disease is chromophobe renal cell carcinoma.