Tumor cells have long been recognized to actively degrade and remodel the ECM from the surrounding benign tissue environment to facilitate tumor expansion and invasion.[9] Laminins are crucial basement membrane components of the lung that play essential roles to support luminal cells while limiting apical‐to‐basolateral cell migration.[39] Intriguingly, immunofluorescence analysis of Laminin distribution in the dECM‐tumor tissues revealed a reduction in LAMA1 abundance specifically within regions populated by the tumor nodes (Figure S2, Supporting Information). The gene discussed is LAMA1; the disease is neoplasm.