LAMB2 and neoplasm: In parallel to aggressively digesting the surrounding benign tissue environments, tumor cells are also well known to actively lay down their own ECM species to build a more favorable extracellular environment for themselves to thrive.[9] Comparing the newsECM profiles between the two tumor models, we observed enhanced deposition of structural ECM components including several collagen and laminin subunits in dECM‐tumors compared to tumoroids (Figure 6G,H).