This supports the biological relevance of our tissue models and newsECM profiling, as overexpression of MMP14 is frequently associated with excessive tumor ECM remodeling, migration, and metastasis.[40, 41] In parallel to eluates, we also searched the bulk proteomics results of input samples from both dECM‐tumors and tumoroids, and were not able to detect MMP‐14, further demonstrating the augmented sensitivity of newsECM profiling to identify subtle changes in low‐abundance ECM regulators compared to conventional bulk proteomics. Here, MMP14 is linked to neoplasm.