We observed significantly elevated MMP‐14 presence colocalizing with tumor cell colonization in dECM‐tumors in comparison to tumoroids (Figure 6E,F), which was localized both intracellularly and at the cell surface, shown by co‐localization with E‐cadherin (E‐Cad) (Figure S13, Supporting Information). Here, CDH1 is linked to neoplasm.