PCOLCE2 and lung cancer: In addition to MMP‐14, other ECM digestive regulators, such as Procollagen C‐Endopeptidase Enhancer 2 (PCOLCE2), a predictive marker for epithelial‐to‐mesenchymal transition and metastasis in lung cancer,[43] were also observed with elevated synthesis levels in dECM‐tumors (Figure 6C).