Among the 2088 evaluated proteins, three showed robust evidence of causal association with periodontitis: FGF2 (fibroblast growth factor 2) (odds ratio [OR]: 1.06, 95% confidence interval [CI] 1.032–1.082), AZGP1 (zinc‐alpha‐2‐glycoprotein) (OR: 1.12, 95% CI 1.058–1.189) and BTC (betacellulin) (OR: 0.86, 95% CI 0.789–0.942). The gene discussed is BTC; the disease is periodontitis.