TCF7L2 and major depressive disorder: In addition, this study identified common genetic associations between AN and major psychiatric disorders including schizophrenia, bipolar disorder, and major depression, as well as psychological traits including mood instability, neuroticism, and intelligence, of which several (Csnk2b, Ctsa, Gpx1, P4htm and Tcf7l2) were differentially expressed by the Susceptible and Resistant rats, suggesting that the ABA model might recapitulate some of the genetic variants associated with greater predisposition to AN and other psychiatric traits.