Also, the overexpression of genes, including DYRK1A, RCAN1, RUNX1, ERG, and HMGN1 on human chromosome 21, has been implicated in DS leukemogenesis (Zaslavsky et al. 2013; Rainis et al. 2005; Cabal‐Hierro et al. 2020). The gene discussed is HMGN1; the disease is Dravet syndrome.