Also, a study conducted in 2022 by Francisco Alejandro Lagunas-Rangel and colleagues indicated that a triple-drug combination of GABA, sitagliptin, and a PPI (referred to as A + B + C) was more effective in preventing diabetes onset, increasing C-peptide and insulin levels, lowering blood glucose, and reducing the need for external insulin therapy in severely diabetic mice (Lagunas-Rangel et al. 2022). Here, INS is linked to diabetes mellitus.