SETD5 and congenital anomaly of kidney and urinary tract: As shown in Table 2, the incidence of CAKUT in individuals with ADNP-, SETD5- and PHIP-related disorders in the Baylor Genetics clinical database were significantly higher than the rate of CAKUT in the general population with P values of 0.0444, 0.0079, and 0.0002, respectively.