PDE3B and obesity due to melanocortin 4 receptor deficiency: We see a qualitatively similar effect of burden of rare variation in PDE3B, which is associated with higher overall obesity as measured by body fat percentage, but reduced WHRadjBMI (exome-wide significant), android to gynoid ratio, abdominal fat ratio, and visceral adipose tissue volume (all p < 0.05), indicating that the increased body fat percentage in these individuals may be driven by higher subcutaneous rather than visceral fat accumulation (Figures 2 and S3).